Clinical research has demonstrated that the De Simone Formulation found in Visbiome, can aid in the management of common symptoms related to Irritable Bowel Syndrome (IBS) such as reductions in abdominal pain, flatulence, and bloating. 
Visbiome Formulation has been the subject of clinical trials involving more than 370 adult and pediatric patients in the dietary management of dysbiosis associated with IBS.^{22, 23, 24, 25} 

The De Simone Formulation found in Visbiome is one of the few probiotics with an established clinical response in the dietary management of Ulcerative Colitis (UC).  Visbiome can be used concomitantly with standard drug treatments. Visbiome Formulation has been the subject of eight clinical trials involving more than 500 adult and pediatric patients. A notable study involving 32 adult patients with acute ulcerative colitis yielded a combined 77% remission/response rate with no adverse effects. ²⁶

The De Simone Formulation, found in Visbiome was shown to support patients consuming Antibiotics. Diarrhea is a common side effect of antibiotics. In a clinical trial, none of the patients that received the De Simone Formulation while being treated with antibiotics presented with diarrhea.⁴⁵

In three double-blind, placebo-controlled trials and one open trial, the De Simone Formulation, found in Visbiome, has been shown to aid in the dietary management of pouchitis. In a Clinical trial with 40 patients with chronic relapsing pouchitis, 20 patients consuming the Visbiome Formulation were still in remission after nine months compared to zero in the placebo group.

The De Simone Formulation, found in Visbiome, has been the subject of multiple controlled clinical studies involving over 775 patients. In one placebo-controlled trial involving 160 cirrhotic patients, those consuming the De Simone Formulation for dysbiosis experienced a reduced incidence of HE, reduced ammonia levels, and improvements in psychometric test compared to controls.