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The De Simone Formulation Probiotic

Professor Claudio De Simone invented the De Simone Formulation, a high potency, eight strain probiotic product with a specific biochemical and immunologic profile in the 90’s. The key strains in the De Simone Formulation are proprietary, as are the manufacturing processes and the precise ratios of strains necessary to confer benefit as a medical food.

The De Simone Formulation has been the subject of over 70 published clinical trials going back nearly 20 years.

After Professor De Simone invented the product, the secret formulation, and associated patent, were licensed to the VSL Pharmaceuticals, Inc. company (“VSL Inc”) and was subsequently produced under the brand name, “VSL#3®*” from 2002 to January 2016. When De Simone terminated his relationship with VSL Inc. he partnered with ExeGi Pharma, LLC to market his De Simone Formulation under the brand, VISBIOME.

When De Simone exited his relationship with VSL Inc. they began an effort to reverse engineer the formulation and launched an imitation product, produced in Italy, in 2016.

The effort to copy the product failed and in 2019, a Federal Judge issued a broad injunction preventing VSL Inc from marketing practices which would “…suggest a false continuity between Italian VSL#3 and the De Simone Formulation.”

Today, the De Simone Formulation is available only as Visbiome and Visbiome Extra Strength.


    *VSL#3® is a registered trademark and is manufactured exclusively for, VSL Pharmaceuticals, Inc. Visbiome is manufactured exclusively for ExeGi Pharma and is not affiliated with, endorsed by, or distributed by VSL Pharmaceuticals Inc.

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