What Is Visbiome®?
More than 25 years ago, Professor Claudio De Simone developed his lauded De Simone Formulation probiotic at his lab in Rome.
Today, the De Simone Formulation can be found only in Visbiome, a high potency probiotic medical food containing 8 strains of live bacteria in concentrations of 450 billion per packet and 112.5 billion per capsule – one of the highest concentrations available.

What Is Visbiome®?
More than 25 years ago, Professor Claudio De Simone developed his lauded De Simone Formulation probiotic at his lab in Rome.
Today, the De Simone Formulation can be found only in Visbiome, a high potency probiotic medical food containing 8 strains of live bacteria in concentrations of 450 billion per packet and 112.5 billion per capsule – one of the highest concentrations available.

What Is Visbiome®?
More than 25 years ago, Professor Claudio De Simone developed his lauded De Simone Formulation probiotic at his lab in Rome.
Today, the De Simone Formulation can be found only in Visbiome, a high potency probiotic medical food containing 8 strains of live bacteria in concentrations of 450 billion per packet and 112.5 billion per capsule – one of the highest concentrations available.
What Is Visbiome®?
More than 25 years ago, Professor Claudio De Simone developed his lauded De Simone Formulation probiotic at his lab in Rome.
Today, the De Simone Formulation can be found only in Visbiome, a high potency probiotic medical food containing 8 strains of live bacteria in concentrations of 450 billion per packet and 112.5 billion per capsule – one of the highest concentrations available.

With more than 70 published human clinical studies, it is one of the most widely studied probiotics on the market today, and has been shown to be an effective aid in the management of dysbiosis, or microbial imbalance, associated with:
Irritable Bowel Syndrome (IBS)
Pouchitis
Ulcerative Colitis (UC)
Hepatic Encephalopathy (HE)
What Makes Visbiome® Effective?
Visbiome contains a highly concentrated natural yogurt bacteria which are grown using dairy ingredients to ensure their health and vitality. (Trace levels of dairy may be present in the final product)
Our proprietary cocktail contains the following bacterial strains selected due to their individual characteristics and synergistic activities. They are cultured from proprietary Master Cell Banks and manufactured using specific rations.
Genus |
Species |
Deposit References |
---|---|---|
Lactobacillus | paracasei | DSM 24733/SD5218 |
Lactobacillus | plantarum | DSM 24730/SD5209 |
Lactobacillus | acidophilus | DSM 24735/SD5212 |
Lactobacillus | delbrueckii subspecies bulgaricus* | DSM 24734/SD5210 |
Bifidobacterium | longum± | DSM 24736/SD5220 |
Bifidobacterium | infantis± | DSM 24737/SD5219 |
Bifidobacterium | breve | DSM 24732/SD5206 |
Streptococcus | thermophilus | DSM 24731/SD5207 |
- L. acidophilus DSM24735
- L. plantarum DSM24730
- L. paracasei DSM24733
- L. delbrueckii subsp. bulgaricus‡ DSM24734
- S. thermophilus DSM24731
- B. longum** DSM24736
- B. breve DSM24732
- B. infantis** DSM24737
±Reeclassified as Bifidobacterium lactis
*Reclassified as Lactobacillus helveticus
Dosing Information
Visbiome is intended for use under the supervision of a physician.
Visbiome Extra Strength is a prescription only medical food intended for high-dose applications (900 billion bacteria per packet) under elevated medical supervision.
Visbiome and Visbiome Extra Strength Formulations - All Oral Administration
Product |
Bacteria Count (in CFUs) |
Format/Flavor |
NHRIC Code |
---|---|---|---|
Visbiome Unflavored Powder |
450 Billion per packet |
Unflavored – 30 packets per box |
69355-0412-02 |
Visbiome Capsules |
225 Billion per serving (2 capsules 112.5 billion each) |
Vegetable based capsule – 60 capsules per bottle |
69355-0412-03 |
Visbiome Extra Strength (Dispensed By Prescription) |
900 Billion per packet |
30 packets per Box |
69355-0516-01 |
Peace of Mind with Visbiome® Temperature Monitor
Visbiome is shipped and stored under refrigerated conditions (39-46°, 4-8°C) to ensure vitality. Every order is shipped with a temperature monitoring sensor specifically calibrated for Visbiome. This card helps to ensure your order was not compromised by heat events during transit.
Visbiome can be stored at room temperature for up to one week without adversely affecting potency.
Peace of Mind with Temperature Monitor
Visbiome is shipped and stored under refrigerated conditions (39-46°, 4-8°C) to ensure vitality. Every order is shipped with a temperature monitoring sensor specifically calibrated for Visbiome. This card helps to ensure your order was not compromised by heat events during transit.
Visbiome can be stored at room temperature for up to one week without adversely affecting potency.


Visbiome® Dairy Status
Visbiome® contains traces of milk in the finished product. The lactose levels in all Visbiome® products are well bellow the National Institutes of Health's threshold for the amount of lactose intake generally tolerable by individuals with lactose intolerance**.
The strains of beneficial probiotic bacteria found in Visbiome® and Visbiome® Extra Strength have been fermented using some dairy ingredients to ensure their vitality. While this medium is separated from the bacteria during the manufacturing process, trace levels of dairy components may remain. These levels are extremely small but could have some implications for individuals with sensitivvity to dairy.
If you have sensitivity to dairy, please consult with your healthcare professional prior to taking Visbiome® or Visbiome® Extra Strength.
Visbiome® and Visbiome® Extra Strength contain less than the following amounts of the dairy components lactose and beta-lactoglobulin:
Product | Amount of Lactose | Amount of Beta Lactoglobulin |
---|---|---|
Capsules 112.5B CFUs | 0.54 mg | 0.00108 mg |
Unflavored Packets 450B CFUs | 2.70 mg | 0.0054 mg |
Extra Strength 900B CFUs | 5.40 mg | 0.0108 mg |
**Suchy et al. National Institutes of Health Consensus Developed Conference: Lactose Intolerance and Health. Annals of Internal Medicine. 2010. Vol 152. Available evidence suggests that those with lactose intolerance can ingest at least 12 g of lactose when administered as a single dose with no or minor symptoms. Taking four (4) Visbiome Capsules (for a total of 450 Billon CFUs) would result in ingesting less than 0.01 grams of lactose (approximately 1/100th of a teaspoon of milk).