About Visbiome

What Is Visbiome^®?

More than 25 years ago, Professor Claudio De Simone developed his lauded De Simone Formulation probiotic at his lab in Rome.

Today, the De Simone Formulation can be found only in Visbiome, a high potency probiotic medical food containing 8 strains of live bacteria in concentrations of 450 billion per packet and 112.5 billion per capsule – one of the highest concentrations available.

What Is Visbiome^®?

With more than 75 published human clinical studies, Visbiome products are the most studied multi-strain probiotics on the market today and have been proven as an effective aid in the management of dysbiosis, or microbial imbalance, associated with:

Irritable Bowel Syndrome (IBS)

Ulcerative Colitis (UC)

Antibiotic-Associated Diarrhea (AAD)

Hepatic Encephalopathy (HE)

Pouchitis

What Makes Visbiome® Effective?

Visbiome contains highly concentrated natural yogurt bacteria which are grown using dairy ingredients to ensure their health and vitality. (Trace levels of dairy may be present in the final product).

Our proprietary cocktail contains the following bacterial strains selected due to their individual characteristics and synergistic activities. They are cultured from proprietary Master Cell Banks and manufactured using specific ratios.

L. acidophilus DSM24735
L. plantarum DSM24730
L. paracasei DSM24733
L. delbrueckii subsp. bulgaricus^‡ DSM24734
S. thermophilus DSM24731
B. longum** DSM24736
B. breve DSM24732
B. infantis** DSM24737

Visbiome® Bacteria Strains

Genus	Species	Deposit References
Lactobacillus	paracasei	DSM 24733/SD5218
Lactobacillus	plantarum	DSM 24730/SD5209
Lactobacillus	acidophilus	DSM 24735/SD5212
Lactobacillus	delbrueckii subspecies bulgaricus*	DSM 24734/SD5210
Bifidobacterium	longum±	DSM 24736/SD5219
Bifidobacterium	infantis±	DSM 24737/SD5220
Bifidobacterium	breve	DSM 24732/SD5206
Streptococcus	thermophilus	DSM 24731/SD5207

L. acidophilus DSM24735
L. plantarum DSM24730
L. paracasei DSM24733
L. delbrueckii subsp. bulgaricus^‡ DSM24734
S. thermophilus DSM24731
B. longum** DSM24736
B. breve DSM24732
B. infantis** DSM24737

±Reclassified as Bifidobacterium lactis
*Reclassified as Lactobacillus helveticus

Dairy Status

Visbiome contains trace amounts of milk
Some of the strains of beneficial probiotic bacteria found in in Visbiome® are grown in a dairy environment and then blended with the rest of the strains to obtain the Visbiome Formulation. The bacteria are separated from the growth media however some trace levels of milk can be found in the finished product. Visbiome® contains traces of milk in the finished product.

Visbiome is Lactose-Free
Processing methods eliminate lactose even though other milk components are left behind (similar to lactose-free milk). Lactose was not detectable in amounts greater than 50 parts per million (PPM).

If you have sensitivity to dairy, please consult with your healthcare professional prior to taking Visbiome® or Visbiome® Extra Strength.

A message from the inventor

Monash University, the leader in FODMAP research has also officially certified Visbiome as Low FODMAP. FODMAPs are sugars that aren’t absorbed properly in the gut, triggering symptoms in people with IBS and other gut related conditions. Follow this link to learn more about the LOW FODMAP diet.

Dosing Information

Visbiome is intended for use under the supervision of a physician.

Visbiome Extra Strength is a prescription only medical food intended for high-dose applications (900 billion bacteria per packet) under elevated medical supervision.

Visbiome Formulations - All Oral Administration

Product	Bacteria Count (in CFUs)	Format/Flavor	NHRIC Code
Visbiome Unflavored Powder	450 Billion per packet	Unflavored – 30 packets per box	69355-0412-02
Visbiome Capsules	225 Billion per serving (2 capsules 112.5 billion each)	Vegetable based capsule – 60 capsules per bottle	69355-0412-03
Visbiome Extra Strength (Dispensed By Prescription)	900 Billion per packet	30 packets per Box	69355-0516-01

For the Dietary Management of	Visbiome Capsules Per Day (112.5 Billion CFU)	Visbiome Packets Per Day (450 Billion CFU)	Visbiome Extra Strength Packets Per Day (900 Billion CFU)
Irritable Bowel Syndrome (IBS)	2-4	½-1	¼-½
Antibiotic Associated Diarrhea (AAD) Under Antibiotic Treatment	4-8	1-2	½-1
Antibiotic Associated Diarrhea (AAD) After Antibiotic Treatment	2	½	NA
Ulcerative Colitis (maintenance)	4-8	1-2	½-1
Active Ulcerative Colitis (flaring)	NA	4-8	2-4
Pouchitis	NA	2-4	1-2
Hepatic Encephalopathy (HE)	4-8	1-2	½-1

For the Dietary Management of	Less Than 2 Years	2-5 Years	6-11 Years	12-17 Years
Irritable Bowel Syndrome (IBS)	¼ Packet	½ Packet	½ Packet	½-1 Packet
Ulcerative Colitis (maintenance)	¼ Packet	½ Packet	½-1 Packet	1-2 Packets
Active Ulcerative Colitis (flaring)	¼ - ½ Packet	½-1 Packet	1-2 Packets	2-4 Packets

Peace of Mind with Visbiome® Temperature Monitor

Visbiome is shipped and stored under refrigerated conditions (39-46°, 4-8°C) to ensure vitality. Every order is shipped with a temperature monitoring sensor specifically calibrated for Visbiome. This card helps to ensure your order was not compromised by heat events during transit.

Visbiome can be stored at room temperature for up to one week without adversely affecting potency.