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Visbiome is the ONLY probiotic with the De Simone Formulation.
VSL#3* no longer contains the original De Simone Formulation probiotic blend. The only product that contains the De Simone Formulation is Visbiome, and this formulation has been the subject of more than 100 human clinical studies.
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Table contains product information that is believed to be accurate and is as of October 2024
VSL#3* vs. the De Simone Formulation
In the early 1990s, Professor Claudio De Simone invented The De Simone Formulation, a high potency, eight strain probiotic product intended to aid individuals with gastrointestinal distress.
Professor De Simone’s original partners – VSL Pharmaceuticals’ distributors – previously sold his extensively tested probiotic under the name VSL#3®*. In 2016, De Simone severed his relationship with VSL Pharmaceuticals.
Today the De Simone Formulation is only available in Visbiome.
Mid 1990's
Formula Invented
Professor Claudio De Simone invents The De Simone Formulation, a high-potency, eight-strain probiotic for gastrointestinal distress.
2000’s-2016
Sold Under VSL#3*
The De Simone Formulation is sold under the name VSL#3* by VSL Pharmaceuticals distributors.
2016-2019
VSL Pharmaceuticals Loses Access to the De Simone formulation
After losing access, VSL Pharmaceuticals launches a new probiotic product under the VSL#3* Brand name.
Today
Original Formula Rehomed
The De Simone Formulation found a new home in Visbiome, and remains the subject of extensive clinical research.
Our Money Back Guarantee
If you’re not satisfied, we’re not satisfied. We stand behind our products, that’s why we offer a money-back guarantee for Visbiome products. Money Back guarantee is available for purchases through Visbiome.com, call center, and retail pharmacies nationwide.
250,000+ people use Visbiome.
4.8
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Sherry Sands
GI issues
My gastrointestinal doc gave me a sample box of Visbiome GI Care to try. Within a couple of days it had worked wonders on me! It settled down my lower intestinal area and I feel so much better. This probiotic can’t be compared to others. It works.
I still have to go in for tests for a definite diagnosis (IBS) to my issues but it has eased my discomfort. -
Ralph Wise
Life saving medicine
I have taken this faithfully for 5 years now as prescribed by my doctor, I have been mostly IBS symptom free for all of that time. Because of this supplement I have been able to have a life free of wondering where a toilet is if i leave the house. This has done more to help me than any prescription medicine I have taken over the years. If you got IBS this supplement will help you more than you can imagine.
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Monica Long
A godsend - Finally, relief after YEARS of IBS issues!
I've dealt with GI issues for so many years, during which time I have tried numerous potential remedies. I finally found relief from IBS/GI symptoms and issues, when I started taking Visbiome. It is an absolute must have for me; always in my refrigerator.
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Melissa Delgadillo
The best probiotics!
Since I started taking the Visbiome packets, my digestion is so much more regular. I feel so much lighter and focused in the mornings to do my workouts! I feel better. Thank you Visbiome for a superior product.
2024 ACG Recommendations - UC Patients Who Have Undergone Ileal Pouch Anal Anastomosis (IPAA)
In patients with UC who have undergone IPAA and experience recurrent episodes of pouchitis that respond to antibiotics, the AGA suggests using probiotics for preventing recurrent pouchitis. Barnes et all. 2024
(Conditional recommendation, low certainty of evidence)
Handled with the best care.
Guaranteed.
Backed by science. Trusted by experts.
With over two decades of research and 100+ clinical studies, De Simone Formulation found in Visbiome, delivers clinically tested solutions for gut health. Our high-potency probiotic medical food uses carefully selected bacterial strains to help restore balance, support digestion, and ease complications. Built on a foundation of science and backed by experts, Visbiome is trusted by healthcare professionals and patients alike for real, life-changing relief.
Real People, Real Relief
The Visbiome Blog
Insider Insights From Gut Experts
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Liquid error (snippets/article-card line 85): The format option 'month_day_year' is not a supported format.Irritable bowel syndrome (IBS) refers to a collection of digestive symptoms and is the most common functional gut disorder. It is estimated to affect about 10-15% of the population and is more...
7 min readLiving with IBS: What can y...
Irritable bowel syndrome (IBS) refers to a collection of digestive symptoms and is the most common functional gut disorder. It is estimated to affect about 10-15% of the population and is more...
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Liquid error (snippets/article-card line 85): The format option 'month_day_year' is not a supported format.Being sick often comes with a lot of unwanted side effects. If you’ve had to take antibiotics for an illness, you may have also had the misfortune of experiencing antibiotic...
5 min readDiarrhea as an antibiotic s...
Being sick often comes with a lot of unwanted side effects. If you’ve had to take antibiotics for an illness, you may have also had the misfortune of experiencing antibiotic...
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Liquid error (snippets/article-card line 85): The format option 'month_day_year' is not a supported format.When choosing a new product it’s always important to consider the primary benefits you expect to gain so you can determine which company will provide you with the best value...
2 min readChoosing the best probiotic...
When choosing a new product it’s always important to consider the primary benefits you expect to gain so you can determine which company will provide you with the best value...
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*VSL#3® is a registered trademark and is manufactured exclusively for VSL Pharmaceuticals, Inc. Visbiome® is manufactured exclusively for ExeGi Pharma, LLC and is not affiliated with, endorsed by, or distributed by VSL Pharmaceuticals, Inc.
**2024 ACG Recommendations – UC Patients Who Have Undergone Ileal Pouch Anal Anastomosis (IPAA).