Bloating and flatulence [[[Kim et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil (2005) 17,1-10]]](((Visbiome.com)))

Abdominal pain and discomfort [[[Kim et al. A randomized controlled trial of a probiotic, VSL#3, on gut transitand symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2003; 17:895-904]]](((Visbiome.com)))
[[[Guandalini et al. VSL#3 Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Crossover Study. JPNG. 2010;51: 24-30]]](((Visbiome.com)))
[[[Wong et al. Melatonin Regulation as a Possible Mechanism for Probiotic (VSL#3) in Irritable Bowel Syndrome: A Randomized Double-Blinded Placebo Study. Dig Dis Sci. 2014]]](((Visbiome.com)))
[[[Boonma P, et al. Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients with Irritable Bowel Syndrome. Frontiers. 2021]]](((Visbiome.com)))

Excessive stool frequency [[[Sood et al. The Probiotic Preparation, VSL#3* Induces Remission in Patients with Mild to Moderately Active Ulcerative Colitis. Clinical Gastroenterology and Hepatology 2009;7:1202-1209]]](((Visbiome.com)))
[[[Gionchetti P, et al. Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo-controlled trial. Gastroenterology. 2003b;124(5):1202-1209.]]](((Visbiome.com)))