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Why Visbiome is Clinically Effective in the Dietary Management of IBS

Decades of research support the benefits of the De Simone Formulation, as a medical food, in the dietary management of IBS symptoms.

Take Back Control of Your Microbiome

Living with IBS is overwhelming—bloating, cramping, and unpredictable bathroom trips disrupt your daily life. Recent research shows the key role your gut microbiome (trillions of bacteria in your digestive tract) plays in managing these symptoms. Visbiome® is a medical food that sits at the intersection of diet and medical management for IBS. By promoting a healthier bacterial environment, Visbiome helps manage symptoms where they start—in the gut.

Reduction of Abdominal Pain and Discomfort
Clinical studies have shown Visbiome may reduce abdominal pain and discomfort associated with IBS.¹⁻³
Supports Proper Digestion
Helps break down food more efficiently, reducing bloating and discomfort.⁴
Improvements in Bloating and Gassiness
Patients reported a significant reduction in bloating severity with Visbiome compared to placebo.⁵⁻⁸
Explore the Clinical Research

How Visbiome Helps to Manage Your IBS

While the science is constantly refined, studies show Visbiome works at multiple levels to tackle IBS symptoms head-on. It’s backed by clinical trials demonstrating benefits like reduced abdominal pain and bloating in both children and adults.

Restores Gut Microbial Balance

High concentrations of Lactobacillus, Bifidobacterium, and S. thermophilus help outcompete harmful bacteria and restore harmony in your gut.

Strengthens the Gut Barrier

Visbiome helps strengthen the intestinal barrier, reducing colonic permeability—a factor often linked to the development of IBS symptoms. This stabilization of gut barrier function contributes to a reduction in gut inflammation and symptom severity.

Produces Short-Chain Fatty Acids (SCFAs)

The beneficial bacteria in Visbiome help ferment dietary fibers, producing short-chain fatty acids (SCFAs), such as butyrate. SCFAs play a crucial role in nourishing colon cells, reducing inflammation, and promoting overall gut health—key factors in alleviating IBS symptoms.

Modulates the Gut-Brain Axis

The gut microbiome plays a significant role in the gut-brain axis, the bidirectional communication between the gut and the brain. Some probiotic strains have been shown to positively influence this communication, potentially reducing the anxiety and stress that can trigger or exacerbate IBS symptoms

Explore Visbiome Products

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If you’re not satisfied, we’re not satisfied. We stand behind our products, that’s why we offer a money-back guarantee for Visbiome products. Money Back guarantee is available for purchases through Visbiome.com, call center, and retail pharmacies nationwide.

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250,000+ people use Visbiome.

4.8

Based on 7435 reviews
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  • Sherry Sands

    GI issues

    My gastrointestinal doc gave me a sample box of Visbiome GI Care to try. Within a couple of days it had worked wonders on me! It settled down my lower intestinal area and I feel so much better. This probiotic can’t be compared to others. It works.
    I still have to go in for tests for a definite diagnosis (IBS) to my issues but it has eased my discomfort.

  • Ralph Wise

    Life saving medicine

    I have taken this faithfully for 5 years now as prescribed by my doctor, I have been mostly IBS symptom free for all of that time. Because of this supplement I have been able to have a life free of wondering where a toilet is if i leave the house. This has done more to help me than any prescription medicine I have taken over the years. If you got IBS this supplement will help you more than you can imagine.

  • Monica Long

    A godsend - Finally, relief after YEARS of IBS issues!

    I've dealt with GI issues for so many years, during which time I have tried numerous potential remedies. I finally found relief from IBS/GI symptoms and issues, when I started taking Visbiome. It is an absolute must have for me; always in my refrigerator.

  • Melissa Delgadillo

    The best probiotics!

    Since I started taking the Visbiome packets, my digestion is so much more regular. I feel so much lighter and focused in the mornings to do my workouts! I feel better. Thank you Visbiome for a superior product.
Read all Reviews

Passionate experts striving for your relief.

The team at Visbiome work toward one common goal: your wellness and symptom relief. Visbiome was founded in 2015 by Marc Tewey and Yamil Hernández, two pharmaceutical industry veterans with a passion for probiotics. From the beginning, their goal was to continue Professor Claudio De Simone’s legacy of innovation in probiotics and develop a portfolio of new probiotics and live biotherapeutics (probiotic drugs) for both people and pets.

Handled with the best care.

Guaranteed.

Visbiome products are stored and shipped refrigerated to maintain the potency of live bacterial strains. Each shipment includes a temperature sensor which tracks the temperature during transit and ensures it remains within the optimal range for potency.

Backed by science. Trusted by experts.

Backed by 100+ clinical studies and 20+ years of research. Designed for real symptom relief.

Visbiome has been at the forefront of probiotic research for over two decades, developing clinically tested solutions for gut health. Our high-potency probiotic medical food is formulated with carefully selected bacterial strains to restore balance, support digestion, and ease IBS complications. With a foundation in science and expert-backed innovation, Visbiome is trusted by healthcare professionals and patients alike to deliver real, life-changing symptom relief.

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Real People, Real Relief

The Visbiome Blog

Insider Insights From Gut Experts

  • Living with IBS: What can you do about it?

    ...

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    Irritable bowel syndrome (IBS) refers to a collection of digestive symptoms and is the most common functional gut disorder. It is estimated to affect about 10-15% of the population and is more...

    7 min read

    Living with IBS: What can y...

    Irritable bowel syndrome (IBS) refers to a collection of digestive symptoms and is the most common functional gut disorder. It is estimated to affect about 10-15% of the population and is more...

  • IBS vs. Gluten Intolerance. What is the difference?   

    ...

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    Confused about the difference between IBS and gluten intolerance? This blog post explores the similarities and differences between these two conditions, including their symptoms, causes, and treatment options.

    4 min read

    IBS vs. Gluten Intolerance....

    Confused about the difference between IBS and gluten intolerance? This blog post explores the similarities and differences between these two conditions, including their symptoms, causes, and treatment options.

  • Love and GI issues: IBS and Dating

    ...

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    Dating in the modern world is incredibly difficult. It is hard to find the right person, but it is even harder when you have a lot of gas and pain...

    4 min read

    Love and GI issues: IBS and...

    Dating in the modern world is incredibly difficult. It is hard to find the right person, but it is even harder when you have a lot of gas and pain...

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Frequently Asked Questions

Are probiotics good for IBS?

Research indicates that certain probiotic formulations can benefit individuals diagnosed with irritable bowel syndrome (IBS). For instance, clinical studies have shown that Visbiome reduces a constellation of IBS symptoms, including bloating, flatulence, and abdominal discomfort.

The exact mechanisms by which Visbiome aids in the dietary management of IBS are still under investigation. However, it’s believed that Visbiome helps promote a healthy gut microbiome composition and strengthens the intestinal barrier, both of which are compromised in people
with IBS.

What Is The Best Probiotic For IBS Symptoms?

Visbiome high-potency probiotic medical foods are specially formulated for the dietary
management of dysbiosis associated with irritable bowel syndrome (IBS). Clinical studies indicate that Visbiome improves the balance of beneficial gut bacteria and strengthens the intestinal barrier, which is often compromised in individuals with IBS. Further research shows that Visbiome effectively reduces abdominal pain, discomfort, bloating, and gas associated with IBS.

What Makes Visbiome Different From Other Probiotics For IBS?

Visbiome probiotic formulations have several unique features:
● High Potency: Visbiome is a high-potency probiotic, offering doses from 112.5 to 900
billion CFUs, making it one of the most concentrated options available.
● Medical Food: Visbiome is classified as a medical food, specially formulated for the
dietary management of dysbiosis associated with IBS and several other conditions.
● Optimal Storage Conditions: Visbiome is shipped and stored under cool conditions,
which is essential for maintaining potency and effectiveness.

In addition to these advantages, Visbiome is the most highly-researched multi-strain probiotic on the market, with over 100 clinical studies of its proprietary formulations since the 1990s.

Can probiotics help with IBS bloating?

Clinical studies have shown that Visbiome reduces bloating and flatulence (gas). Participants In several clinical studies reported decreased bloating and gas when taking Visbiome compared to a placebo.

Probiotics may reduce bloating by improving the balance of beneficial bacteria in the gut, which enhances digestive functioning, reduces gut inflammation, and improves stool motility. ¹·²·³·⁵

Can Probiotics Help With IBS Abdominal Pain?

Yes, in several controlled clinical trials the probiotic formulation in Visbiome has been show to help support the dietary management of abdominal pain and discomfort resulting from irritable bowel syndrome (IBS). ³·⁴·⁹

References

1: Kim et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil (2005) 17,1‐10 from VisiBiome.com

2: Kim et al. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea‐predominant irritable bowel syndrome. Aliment Pharmacol Ther 2003; 17:895‐904 from VisiBiome.com

3: Wong et al. Melatonin Regulation as a Possible Mechanism for Probiotic (VSL#3) in Irritable Bowel Syndrome: A Randomized Double‐Blinded Placebo Study. Dig Dis Sci. 2014 from VisiBiome.com

4: Bazzocchi, G., Gionchetti, P., Almerigi, P.F., Amadini, C., Campieri, M. Intestinal microflora and oral bacteriotherapy in irritable bowel syndrome. Digestive and Liver Diseases 2002; 34(2):S48‐53.

5: Guandalini et al. VSL#3® Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo‐Controlled, Double Blind, Crossover Study. JPGN. 2010;51:24‐30

6: Staudacher, H., et al. A Diet Low in FODMAPS Reduces Symptoms in Patients with Irritable Bowel Syndrome and a Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial. Gastroenterology 2017;153:936‐947

7: Ng S.C., Lam E.F., Lam T.T., Chan V., Law W., Tse P., Kamm M.A., Sung J.J., Chan F.K., Wu J. Effect of probiotic bacteria on the intestinal microbiota in irritable bowel syndrome. Journal of Gastroenterology and Hepatology 2013; 28(10):1624‐31. doi: 10.1111/jgh.12306

8: Boonma P, et al. Frontiers in Pain Research. 2021

9: Kim SE, et al. Change of Fecal Flora and Effectiveness of the Short‐Term VSL#3® + Probiotic Treatment in Patients with Functional Constipation. J. Neurogastroenterol Motil. 2015 Jan 1, 21 111‐20.

10: Michail S, Kenche H. Gut Microbiota is Not Modified by Randomized, Double‐Blind, Placebo‐Controlled Trial of VSL#3® in Diarrhea‐Predominant Irritable Bowel Syndrome. Probiotics Antimicro. Prot. 2011 3:1‐7.

11: Bibiloni et al. VSL#3® Probiotic‐Mixture Induces Remission in Patients with Active Ulcerative Colitis. Am J Gastroenterology 2005;100:1539‐1546 from VisiBiome.com

12: Tursi A, et al. Low‐dose balsalazide plus high‐potency probiotic preparation is more effective than balsalazide alone or mesalazine in the treatment of acute mild‐ to moderate ulcerative colitis. Med Sci Monit. 2004;10:126‐131 from VisiBiome.com

13: Huynh Hien Q, et al. Probiotic Preparation VSL#3® Induces Remission in Children with Mild to Moderate Acute Ulcerative Colitis: A Pilot Study. Inflamm Bowel Dis 15: 760‐768 (2009)

14: Sood et al. The Probiotic Preparation, VSL#3® Induces Remission in Patients with Mild to Moderately Active Ulcerative Colitis. Clinical Gastroenterology and Hepatology 2009;7:1202‐1209 from VisiBiome.com

15: Tursi A, et al. Treatment of Relapsing Mild‐to‐Moderate Ulcerative Colitis With the Probiotic VSL#3® as Adjunctive to a Standard Pharmaceutical Treatment: A Double‐Blind, Randomized, Placebo‐Controlled Study. Am J Gastroenterol. 105:2218‐27 (2010)

16: Lee J, Moon G., et al. Effect of a probiotic preparation (VSL#3®) in patients with mild to moderate ulcerative colitis. Korean J Gastroenterol Vol. 60 n. 2 94‐101 (2012)

17: Ng S.C, et al. Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis. Inflamm Bowel Dis. 2010;16:1286–1298.

18: Miele E, et al. Effect of a probiotic preparation (VSL#3®) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol. 2009;104:437–443.

19: C.P. Selinger et al. Journal of Hospital Infection 2013 Jun;84(2):159–65

20: Gionchetti P, et al. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double‐blind, placebo‐controlled trial. Gastroenterology 2000;119(2):305–309.

21: Gionchetti P, et al. Prophylaxis of pouchitis onset by probiotic therapy: A double‐blind, placebo‐controlled trial. Gut 2003;12:4(5):1202–1209.

22: Mimura T, et al. Once daily high dose probiotic therapy VSL#3® for maintaining remission in recurrent or refractory pouchitis. Gut. 2004;53(1):108–114.

23: Pronio, et al. A probiotic preparation in patients with Ileal Pouch–Anal Anastomosis for Ulcerative Colitis Is Associated with Expansion of Mucosal Regulatory Cells. Inflamm Bowel Dis 2008;14:662–668.