What is most important to know about Visbiome?

8 strains of live bacteria

Visbiome® is a high potency probiotic medical food, containing 8 strains of live bacteria in concentrations of 450 billion bacteria per packet and 112.5 billion bacteria per capsule. 

De Simone Formulation, the most widely-studied formula

Visbiome® contains the De Simone Formulation, one of the most widely studied probiotics with over 70 published human clinical studies. 

irritable bowel syndrome (IBS), ulcerative colitis (UC), pouchitis, and hepatic encephalopathy (HE)

Visbiome® is a high potency probiotic medical food intended for the dietary management of dysbiosis associated with irritable bowel syndrome (IBS), ulcerative colitis (UC), pouchitis, and hepatic encephalopathy (HE). 

shipped cold

Visbiome® is shipped and stored under refrigerated conditions (39-46°F, 4-8°C) to ensure maximum potency.

Satisfaction Program

Backed by our Satisfaction Program - Money Back Guarantee.

medical food

Visbiome® is a medical food intended for use under the supervision of a physician.


Visbiome® is non-GMO, gluten free, and made in the USA.

Non-Prescription Visbiome® is available in the following formats:

Visbiome Unflavored Powder
450 billion bacteria per packet available in 30 count boxes

Visbiome Capsules
112.5 billion bacteria per capsule available in 60 count bottles


Visbiome® is also available as a prescription only medical food for high-dose applications under elevated medical supervision.

Peace of Mind with Temperature Monitor

Your order includes the following card, which incorporates a temperature monitoring sensor.  This sensor is specially calibrated for Visbiome, and helps ensure your order did not experience impactful heat events during transit to you. 

 temperature monitor

Consists of the Original De Simone Formulation

(which was previously sold under the brand name VSL#3®* until July 2016)

Table reflects status of products as of May 2019.

Visbiome logo
VSL3®* made After
July 2016
Contains proprietary
“De Simone Formulation” probiotic
Published, Peer-Reviewed, Controlled Trials 70+ X
(As of chart publication date)
Probiotic Strains L. acidophilus DSM24735
L. plantarum DSM24730
L. paracasei DSM24733
L. delbrueckii subsp. bulgaricus DSM24734
S. thermophilus DSM24731
B. longum DSM24736
B. breve DSM24732
B. infantis DSM24737
Strain designation numbers are undisclosed at this time.
Only genus and species disclosed.
Fermentation Medium Dairy based Synthetic non-dairy medium
Shipping Conditions Shipped insulated in cold containers and monitored with temp sensors NOT monitored with temp sensors
Manufacture/Country of Origin Manufactured in USA Manufactured in Italy
Cornstarch Status Capsules and Extra Strength Visbiome cornstarch free. Visbiome Unflavored contains cornstarch. All formulations contain cornstarch
Availability in Canada Available
Health Canada Licensed
Natural Health Product

*VSL#3® is a registered trademark and is manufactured exclusively for, VSL Pharmaceuticals, Inc. Visbiome is manufactured exclusively for ExeGi Pharma and is not affiliated with, endorsed by, or distributed by VSL Pharmaceuticals Inc.  ExeGi Pharma, LLC and VSL Pharmaceuticals, Inc. are different companies and have no affiliation with each other.

Product Stocking Codes

Many pharmacies will special order Visbiome and Visbiome Extra Strength from their local wholesalers. Please reference the following Product Codes went discussing with your pharmacist. Visbiome products can also be purchased directly on this website.

 Product Bacterial Count (in CFUs) Format/
Product Code Cardinal Health Amerisource Bergen
Visbiome Unflavored Powder 450 Billion per packet Unflavored - 30 packets per box 69355-0412-02 5220280 10159178
Visbiome Capsules 225 Billion per serving
(2 capsules, 112.5 Billion each)
Vegetable-based capsule -- 60 capsules per bottle 69355-0412-03 5220298 10159621
Visbiome Extra Strength
(Dispensed By Prescription)
900 Billion per packet 30 packets per box 69355-0516-01 5220355 10159177

Dairy Status of Visbiome® and Visbiome® Extra Strength

The strains of beneficial probiotic bacteria in Visbiome and Visbiome Extra Strength are highly concentrated natural yogurt bacteria. These bacteria are fermented using some dairy ingredients to ensure their health and vitality. During the manufacturing process this fermentation “medium” is separated from the bacteria, but some trace levels may remain which contain dairy components. The level of dairy is extremely small but could have implications for some people with sensitivity to dairy. Please consult with your healthcare professional if you have sensitivity to dairy and are considering Visbiome or Visbiome Extra Strength.

Visbiome and Visbiome Extra Strength contain less than the following amounts of the dairy components lactose and beta-lactoglobulin:

Product Amount of Lactose
Capsules 112.5B CFUs 0.54 mg
Unflavored Packets 450B CFUs 2.70 mg
Extra Strength 900B CFUs 5.40 mg


Product Amount of Beta Lactoglobulin
Capsules 112.5B CFUs 0.00108 mg
Unflavored Packets 450B CFUs 0.0054   mg
Extra Strength 900B CFUs 0.0108   mg