A Revolutionary Idea Grows

When Professor Claudio De Simone, M.D., began to develop his eight-strain, high potency probiotic, global recognition and appreciation of the human microbiome was only beginning to take root.

As decades passed and advances in technology gradually allowed scientists to more fully understand the complex community of microorganisms sharing a symbiotic relationship with human life, Professor De Simone worked alongside experts in inflammatory bowel disease, liver diseases, IBS, and oncology to perfect his invention.

What resulted was one of the most comprehensively studied probiotics on the market today: The De Simone Formulation.

The De Simone Formulation Probiotic

The De Simone Formulation is a probiotic medical food containing living bacteria. It is the driving force behind Visbiome®, which aids in the dietary management of microbial imbalance associated with IBS, ulcerative colitis, pouchitis, and hepatic encephalopathy.

Key attributes of the De Simone Formulation include:

  • An eight-strain cocktail cultured from Master Cell Banks, including: 

Genus

Species

Deposit References

Lactobacillus paracasei DSM 24733/SD5218
Lactobacillus plantarum DSM 24730/SD5209
Lactobacillus acidophilus DSM 24735/SD5212
Lactobacillus delbrueckii subspecies bulgaricus* DSM 24734/SD5210
Bifidobacterium longum± DSM 24736/SD5220
Bifidobacterium infantis± DSM 24737/SD5219
Bifidobacterium breve DSM 24732/SD5206
Streptococcus thermophilus DSM 24731/SD5207

±Reclassified as Bifidobacterium lactis
*Reclassified as Lactobacillus helveticus 

  • Implementation of specific strain ratios.
  • Proprietary methods of manufacturing and processing.

There is Only ONE De Simone Formulation

The De Simone Formulation was previously sold under the name VSL#3®* by VSL Pharmaceuticals and its distributors.

When Professor De Simone severed his relationship with the company in July 2016, however, his former partners attempted to sell an untested version of the product, passing it off as the original formula, and neglecting to inform patients or physicians of the change. Click here to read Professor De Simone's thoughts on the verdict.

In 2019, the distributors of VSL#3®* were found liable of false advertising by a federal court and ordered not to state or suggest a false continuity between VSL#3 and the De Simone Formulation.

*VSL#3® is a registered trademark and is manufactured exclusively for, VSL Pharmaceuticals, Inc. Visbiome is manufactured exclusively for ExeGi Pharma and is not affiliated with, endorsed by, or distributed by VSL Pharmaceuticals Inc.

There is only one De Simone Formulation. And Visbiome® has it.

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